Sunday, October 21, 2012

Moody...Drink a cup of Coffee. Why Caffeine? Read More

Today I want to share about Caffeine and Its effects on Mood. I smell fragrance of rich. Waaa... I want a cup of coffee. Ok so what is the effects????

Mood is a complex and poorly defined psychic phenomenon. It holds the underlying psychological and behavioral functions (Fredholm, 1999). There is an old saying, “There is nothing either good or bad, but thinking makes it so”, but it does not express the supreme power of moods over the quality of life (Weinberg& Bealer, 2002). Does caffeine has any effects on mood? There is ample evidence that lower doses (20-200mg) of caffeine are reliably associated with “positive” subjective effects even in the absence of acute withdrawal effects (Fredholm, 1999).

Adenosine play important role in depression. Adenosine receptor in platelet is blunted due to excess adenosine transmission in patient with major depression (Berk et al, 2001). As stated earlier caffeine is an antagonist of adenosine. Therefore, it has positive potentials in the treatment of depression due to increased platelet aggregation in this disorder (Musselman et al, 1996). Furthermore by blocking adenosine receptor may increase the level of cathecolamines and serotonin (Fredholm, 1999). In this respect, it is relevant that caffeine can increase serotonin release in limbic areas and dopamine release in the prefrontal cortex to give the same effects as antidepressant (Acquas et al, 2002).

To clarify, caffeine combats depression by helping to restore the balance of serotonin system, the same system that the antidepressant Prozac and Zoloft regulate in order to overcome gloom (Weinberg& Bealer, 2002). Caffeine gives our moods a positive effect by stimulating the norepinephrine system, a system regulated by such antidepressant as Welbutrin (Weinberg& Bealer, 2002). Besides, it has reinforcing activity to the activation of the dopamine system (Smith, 2002). Real mood effects from caffeine emerge more slowly than effects on cognitive performance. Effects on attention span, for example, are seen between 30 minutes and 1 hour after taking caffeine, while mood effects taken 1 to hours to develop (Smith, 1991).


Caffeine has ability to combat the depression that lead to suicide. A decade long study of women nurses, done by Kawachi and the colleagues (1996) demonstrated that the suicide rate was inversely related to the amount of caffeine the women consumed. Caffeine also make the subjects feels more relax and less hostile when confronted when hostile person and situations. Smith and the colleagues (1997) had administered mental arithmetic and anagram test while harassing their subjects (“ come on you can do better than that”) found that the combination of caffeine and stress pushed the participant past the peak of Yerkes-Dodson curve of arousal, causing them feel more relax and blood pressure fall.

Caffeine increases feelings of optimism and self-confidence and dispels boredom and fatique (Weinberg& Bealer, 2002). Caffeine slow the process of boredom due to repetitive activity or unchanging situation by make things seems something more interesting for longer time (Davidson& Smith, 1989). Scientific study proof, caffeine boost workplace performance, a massive study of 85,000 female nurses conducted by Kawachi et al (1996) demonstrating, 100mg of caffeine per day produced increase feeling of well-being, social disposition, self confidence, energy and motivation to work.

To conclude caffeine benefits on mood is ample. Subjects reported that they feel energetic, imaginative, efficient, self-confident, and alert, they feel able to concentrate and are motivated to work and also have the desire to socialize (Griffiths& Mumford, 1995). Schoolchildren consuming more than 50mg of caffeine per day, mainly from soft drink, report higher wakefulness than a control group consuming less than 10 mg per day (Goldstein& Wallace, 1997). Smith (1997) in his study, found that subjects with upper respiratory tract illness ( “ common cold ” ) were not only feeling more alert after consuming caffeine but also were performing better in reaction time task, something they did not do when they were feeling well.


Fredholm B.B, Batting K, Holmen J, Nehlig A & Zvartan E.E. (1999). Action of caffeine in the brain with special reference to factors that Contribute to its widespread use. Pharmacological reviews, 51,83-133.
Goldstein A,Wallace M.E. (1997). Caffeine dependence in schoolchildren? Exp Clin Psychopharmacol  5, 388-392.
Griffiths R.R, Mumford G.K. (1995). Caffeine---A drug of abuse? Psychopharmacology: The Fourth Generation of Progress, 1699-1713.
Acquas, E. Tanda, G. &  Di Chiara, G. (2002). Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-na├»ve and caffeine-pretreated rats. Neuropsychopharmacology, 27, 182-193.
Weinberg B.A., Bealer B.K. (2001). The Caffeine Advantage: How to Sharpen your Mind, Improve your Physical Performance, and Achieve Your Goals- the Healthy Way. A Division of Simon & Schuster Inc, America.


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